BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a debilitating chronic condition characterized by an excessive increase in heart rate when transitioning from a lying or sitting position to standing. It impacts millions of people globally and is linked to a wide range of subsequent symptoms.

CASE REPORT: This case report describes the novel use of stellate ganglion block (SGB) in a 41-year-old woman with a 15-year history of debilitating POTS symptoms. Given the failure of conservative management, the clinical team pursued a left SGB. Nine weeks postprocedure, the patient reported a pulse in the normal range under 100 beats per minute and 100% resolution of all symptoms that affected her quality of life.

CONCLUSIONS: The application of an SGB led to a remarkable reduction in the symptoms from POTS in this patient, showcasing its promise as a novel therapeutic strategy. This innovative approach not only alleviated the patient’s distress but also opened new avenues for treatment.

KEYWORDS: POTS, Stellate ganglion block, autonomic, case report